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Leadership & Advisory

Clinician-Built. Execution-Focused. Board-Supported.

NEG+ Innovations is led by a physician-scientist with deep translational medicine, oncology drug development, and medical device expertise — supported by an advisory board assembled for complete commercialization coverage across regulatory, clinical, engineering, and capital domains.

Jimmy Belotte, MD PhD MBA FACOG — Founder & CEO, NEG+ Innovations
Jimmy Belotte
MD  ·  PhD  ·  MBA  ·  FACOG
Founder & Chief Executive Officer
NEG+ Innovations, Inc.

Physician-Scientist.
Inventor & Co-Investor. Women's Health Executive.

Dr. Jimmy Belotte is a board-certified OB/GYN, physician-scientist, and inventor whose work sits at the intersection of women's health surgical innovation, translational medicine, and medical device entrepreneurship. As Medical Director, Oncology Clinical Development at GlaxoSmithKline, he leads regulatory strategy and protocol design across Phase I/II gynecologic oncology programs — directly informing NEG+'s clinical development and regulatory approach within the broader women's health landscape.

Dr. Belotte's academic foundation — including a PhD in Reproductive Physiology and an MBA with concentrations in healthcare and finance — positions him at the intersection of clinical rigor, translational science, and venture-grade business execution. As both inventor and co-investor in NEG+ Innovations, he brings the rare combination of hands-on surgical insight and capital commitment that defines founder-led medtech. As Former Clinical Associate Professor at Albert Einstein College of Medicine, he maintains active academic clinical relationships that serve as the backbone of NEG+'s investigator network and NIH STTR academic partnership strategy.

NEG+ Innovations was built from a clinical problem-first perspective: each device in the portfolio emerged directly from documented deficiencies Dr. Belotte encountered in women's health surgical practice — then validated through voice-of-customer research, engineering feasibility, and market analysis before a single patent was filed. Every invention carries both his intellectual and financial conviction.

Medical Director, Oncology GlaxoSmithKline · Phase I/II Gynecologic Oncology
Former Clinical Associate Professor Albert Einstein College of Medicine / Montefiore
MD, PhD, MBA, FACOG OB/GYN · Gynecologic Oncology · Molecular Medicine
Medical Device Entrepreneur Founder · NEG+ Innovations, Inc. (Delaware C-Corp)
Regulatory & Clinical Strategy FDA 510(k) · De Novo · IDE · NIH STTR/SBIR
Capital Formation SAFE · Series Seed · QSBS · Non-Dilutive NIH Funding

Board of Directors

NEG+ Innovations is governed by a Board of Directors combining physician-scientist founding leadership with deep technology commercialization, precision engineering, and life science instrumentation expertise.

Jimmy Belotte
Jimmy Belotte
MD  ·  PhD  ·  MBA  ·  FACOG
Founder & Board Chair · CEO
NEG+ Innovations, Inc.  ·  GlaxoSmithKline

Physician-scientist and serial medtech entrepreneur. Board-certified OB/GYN and gynecologic oncologist; Medical Director, Oncology Clinical Development at GlaxoSmithKline; Former Clinical Associate Professor, Albert Einstein College of Medicine / Montefiore. PhD in Reproductive Physiology. MBA with concentrations in healthcare and finance. Founded NEG+ from documented clinical unmet needs across the women's pelvic health surgical and diagnostic landscape.

Executive Resume →
Michael Chiu PhD
Michael Chiu
PhD  ·  MBA
Director
CEO, Kytopen, Inc.  ·  MIT Precision Engineering

Serial life science technology CEO with a PhD and MS from MIT (Precision Engineering Research Group) and an MBA from MIT Sloan Fellows. Current CEO of Kytopen (cell engineering platform). Prior CEO of Erbi Biosystems, acquired by Merck KGaA / MilliporeSigma. Former CTO and executive at Automation Engineering Inc. (acquired by Mycronic AB) and Teradyne. Nine patents across precision engineering, medical devices, and cell therapy. R&D 100 Award recipient.

LinkedIn Profile →

Expert Advisory Board. Complete Commercialization Coverage.

NEG+ has assembled a multi-disciplinary Advisory Board spanning FDA regulatory strategy, clinical validation, engineering execution, investor access, life sciences partnerships, health economics, and corporate finance — each member occupying a defined, non-redundant value lane built for full commercialization coverage.

Roger Lefevre MD MBA
Roger Lefevre, MD, MBA
Urogynecology & Reconstructive Pelvic Surgery

Clinical Validation — Urogynecology & POP-Q

BIDMC · Beth Israel Lahey Health · Harvard Medical School
  • Urogynecologist & URPS specialist, BIDMC / Harvard Medical School · 20+ years practice
  • Prospective STTR academic PI for POP-Q AutoSense™ clinical validation program
  • Peer-reviewed publication record in POP-Q methodology, prolapse staging, and surgical outcomes
Mark D. Levie MD
Mark D. Levie, MD
Professor & Associate Vice Chair, OB/GYN

Clinical Validation — Minimally Invasive Gynecologic Surgery

Albert Einstein College of Medicine · Montefiore Medical Center
  • Professor & Associate Vice Chair, OB/GYN · Albert Einstein / Montefiore Medical Center
  • Director, Minimally Invasive Gynecologic Surgery · 37 years clinical practice
  • Co-investigator candidate for Belotte Colpotomizer™ MIGS feasibility studies
Bethany Grant
Bethany Grant
BS/SM · MIT Aeronautical & Astronautical Engineering

Medical Device Engineering Leadership

Chief Technology Officer · Kytopen, Inc.
  • MIT-trained engineer · BS/SM Aeronautical & Astronautical Engineering · 25+ years medtech
  • CTO, Kytopen · Former VP Product Development · precision engineering & R&D leadership
  • Applicable expertise across pharmaceutical, medtech, and life science instrumentation sectors
John Bonham-Carter
John Bonham-Carter
Bioprocessing & Cell Therapy · European Biopharma

Bioprocess Engineering & International BD

Life Sciences · Continuous Bioprocessing & Cell Therapy
  • Deep expertise in continuous bioprocessing, bioreactor technology, and cell therapy engineering
  • Fluent in French and Swedish; extensive European biotech and biopharma network
  • Supports NEG+'s international BD strategy and bioprocess-adjacent partnerships
Ludwick Alexis
Ludwick Alexis
CPA · MBA Chicago Booth · Director, Walmart

Accounting & Finance — Consultant

Director, Sam's Club Merchandise Portfolio Finance · Walmart
  • Director, Sam’s Club Merchandise Portfolio Finance · Walmart · MBA, University of Chicago Booth
  • CPA; 10+ years Deloitte Senior Manager, Audit & Assurance (healthcare, retail, broker-dealer)
  • Advises on financial reporting, internal controls architecture, and fiscal governance
Owen Chiu
Owen Chiu
Engineering Consultant

Engineering — Consultant

Product Engineering & Development
  • Mechanical engineering and product development with Baja SAE design competition experience
  • Supports device prototyping, CAD design iteration, and engineering documentation
  • Northeastern University engineering graduate
Amjad Zakka MD
Amjad Zakka, M.D.
MD · MPH Brandeis Heller · Volunteer Research Assistant to CEO

Volunteer Research Assistant — CEO

Research Planning · Scientific Writing · Protocol Design
  • MD, University of Aleppo · MPH, Brandeis Heller School; Teaching Assistant
  • International humanitarian medicine: Norwegian Refugee Council, Caritas, Medair
  • Supports literature review, protocol design, manuscript drafting, and regulatory document preparation

FDA Regulatory

Former FDA Principal Deputy Commissioner

Exceptional regulatory access and strategic pathway expertise — a resource most medtech startups at any stage do not have. Key lane: 510(k) / De Novo / IDE strategy.

Clinical Validation — Urogynecology

KOL · Urogynecology

Clinical champion for POP-Q AutoSense™ and Belotte Colpotomizer™. Reduces IDE activation friction; serves as STTR PI candidate at an established NIH-funded institution.

Engineering & Quality Systems

Repligen / SelasBio

Mechanical engineering execution, FDA design controls (21 CFR Part 820), ISO 13485 QMS implementation, and Design History File architecture.

Capital Access — Angel & Early VC

Boston Harbor Angels

Medtech angel and early-stage VC network access. Investor relations strategy, pitch positioning, and seed round pipeline for Series Seed target investors.

Life Sciences Partnerships

Biopharma CVC & Growth-Stage

Corporate venture capital and biopharma strategic partnership lane. Growth-stage business development relationships and strategic acquirer relationship development.

Health Economics & Policy

Brandeis University / Harvard School of Public Health

Healthcare economics, reimbursement strategy, CPT code development pathway, and SBIR/STTR narrative framework for NIH Specific Aims alignment.

Corporate Finance & Legal

Investor governance, SAFE documentation, cap table management, IP agreement architecture, and Series Seed transaction readiness for institutional venture investors.

Intellectual Property & Patent Counsel

Boutique patent and trademark law firm managing prosecution and portfolio strategy across all NEG+ device programs. Extensive experience in mechanical, chemical, and electrical disciplines with international IP prosecution capabilities through global firm networks.

"In more than two decades of urogynecologic practice, I have witnessed firsthand how subjective POP-Q examination leads to inconsistent staging — and, ultimately, inconsistent patient care. The POP-Q Sensorized Device™ represents a meaningful step toward the objective, reproducible pelvic floor assessment our field has long needed. I am committed to supporting its rigorous clinical validation at BIDMC and to advancing a platform that can meaningfully improve outcomes for women with pelvic organ prolapse."

RL
Roger Lefevre, MD, MBA
Urogynecologist  ·  Urogynecology & Reconstructive Pelvic Surgery
Beth Israel Deaconess Medical Center  ·  Beth Israel Lahey Health  ·  Harvard Medical School

Partner With NEG+ Innovations

We welcome collaboration with leading research institutions, clinical investigators, industry partners, and accredited investors who share our commitment to advancing women's health through precision medical technology.